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CCTV News:According to the report of Beijing Health and Health Commission, from 0: 00 to 24: 00 on November 14th, there were 303 locally confirmed cases and 159 asymptomatic infected persons (including one asymptomatic infected person who was transferred to a confirmed case, of which 257 cases were reported), 394 isolated observers and 67 social screening personnel in Beijing, and there were no new suspected cases. Two confirmed cases imported from abroad and two asymptomatic infected persons were added, and no suspected cases were added. 40 cases were cured and discharged, and 6 cases were asymptomatic infected.

Locally confirmed cases:

Confirmed case 1: I now live in Area 1, No.19 Hospital, Shunsha Road, Changping District.

Confirmed cases 2 and 3: I now live in the third phase of Baigezhuang New Village in Changping District.

Confirmed cases 4 and 45: now living in Dianshang Village, Changping District.

Confirmed case 5: now living in Huafu, Longshan, Changping District.

Confirmed case 6: I now live in the junior high school apartment of Wangfu School Foreign Language School, No.11 Wangfu Street, Changping District.

Confirmed case 7: I live in No.116 Dongwei Road, Chaoyang District.

Confirmed case 8: Now living in Laojuntang Village, Chaoyang District.

Confirmed case 9: Now living in No.3 Yard, Runyuan, Yuanyang, Taying North Street, Chaoyang District.

Confirmed case 10: Now living in Hegezhuang Village, Chaoyang District.

Confirmed case 11: now living in No.50 Anzhenyuan Hospital, Chaoyang District.

Confirmed case 12: now living in the south area of Jiugong Xinyuan, Daxing District.

Confirmed cases 13 and 14: I now live at No.25, Wang Hongbin Street, Dongcheng District.

Confirmed case 15: Now living in Lilianghe Village, Huairou District.

Confirmed case 16: I now live in Building 19, Nord Center, Fengtai District.

Confirmed case 17: I now live at No.22 Fengguan Road, Fengtai District.

Confirmed case 18: Now living in Xingfu Jiayuan Community, Fengtai District.

Confirmed case 19: now living in Zhufangdongzhuang, Haidian District.

Confirmed case 20: currently living in No.1 Hospital of Longshan Jiayuan, Mentougou District.

Confirmed cases 21 and 47: I now live in the construction site of Machang subway station in Dongtai Road, Pinggu District.

Confirmed case 22: Now living in Huanle Song Apartment, hong cun, Xihai, Shunyi District.

Confirmed case 23: currently living in Fuheyuan Community, Tongzhou District.

Confirmed case 24: I now live in Building 18, Baiwanzhuang Street, Xicheng District.

Confirmed case 25: now living in Kanghongjiayuan Community, Dongcheng District.

Confirmed cases 26 and 31: now living in the second district of Wangjing Xiyuan, Chaoyang District.

Confirmed case 27: now living in North Lane, South Taipingzhuang, Chaoyang District.

Confirmed case 28: Now living in Shigezhuang Village, Chaoyang District.

Confirmed cases 29 and 30: now living in Xibahe Beili Property Community, Chaoyang District.

Confirmed case 32: now living in Xiaoguan Beili Community, Chaoyang District.

Confirmed case 33: currently living in No.18 Hospital of Zhouzhuang Community, Chaoyang District.

Confirmed case 34: now living in Sibozi Village, Haidian District.

Confirmed case 35: Now living in Jing Yi Li Community, Changqianyuan, Haidian District.

Confirmed case 36: now living in Qiangyou New Town, Haidian District.

Confirmed case 37: I now live at No.13 Majiapu East Road, Fengtai District.

Confirmed case 38: currently living in Area 4, Shimenying New District, Mentougou District.

Confirmed case 39: now living in Lvwan Xingyuan Community, Fangshan District.

Confirmed case 40: Now living in Shengyuan International Community, Tongzhou District.

Confirmed case 41: currently living in Pi Village, Chaoyang District.

Confirmed case 42: now living in the second district of Tiantong Beiyuan, Changping District.

Confirmed case 43: Now living in Tiangezhuang Village, Shunyi District.

Confirmed case 44: now living in the dormitory of Asuwei Waste Incineration Factory in Changping District.

Confirmed case 46: now living in Longyueyuan District 1, Changping District.

All the above are social screening personnel, and they were diagnosed as confirmed cases on November 14th.

Confirmed cases 48 to 61: currently living in Dongcheng District;

Confirmed cases 62 to 87: currently living in Xicheng District;

Confirmed cases 88 to 176: currently living in Chaoyang District;

Confirmed cases 177 to 195: currently living in Haidian District;

Confirmed cases 196 to 205: currently living in Fengtai District;

Confirmed cases 206 to 208: currently living in Shijingshan District;

Confirmed case 209: currently living in Mentougou District;

Confirmed cases 210 to 212: currently living in Fangshan District;

Confirmed cases 213 to 233: currently living in Tongzhou District;

Confirmed cases 234 to 240: currently living in Shunyi District;

Confirmed cases 241 to 295: now living in Changping District;

Confirmed cases 296 to 301: currently living in Daxing District;

Confirmed case 302: now living in Huairou District.

All the above were isolated observers, and were diagnosed as confirmed cases on November 14th.

Locally asymptomatic infected persons:

Asymptomatic Infected Person 1: Now living in Building 12, Baiqiao Street, Dongcheng District.

Asymptomatic Infected Person 2: I now live in Building 8, Guangqumennei Street, Dongcheng District.

Asymptomatic Infected Person 3: Now living in Xiangfengge Dormitory, No.2 A Xinghua Road, Chaoyang District.

Asymptomatic infected person 4: now living in Jinsong District 8, Chaoyang District.

Asymptomatic Infected Person 5: Now living in No.3 Hospital of Yaojiayuan Xili, Chaoyang District.

Asymptomatic infected persons 6 and 7: now living in Shigezhuang Village, Chaoyang District.

Asymptomatic Infected Person 8: Now living in the second phase of Baiwang Molly Garden in Haidian District.

Asymptomatic Infected Person 9: Now living in Building 63, South Third Ring Road, Fengtai District.

Asymptomatic Infected Person 10: Now living in No.7 Hospital of Fenghuayuan West Street, Fengtai District.

Asymptomatic Infected Persons 11 and 12: Now living in the East Zone of Waterfront Yayuan, Fangshan District.

Asymptomatic infected person 13: now living in the second district of Fuyan New Village, Fangshan District.

Asymptomatic infected person 14: Now living in Gucheng Village, Shunyi District.

Asymptomatic infected person 15: Now living in Baimiao Village, Changping District.

Asymptomatic infected person 16: Now living in Beixintun Village, Daxing District.

Asymptomatic Infected Person 17: Now living in Beijing Construction Engineering Dormitory of Huilongguan Sports and Culture Park in Changping District.

Asymptomatic Infected Person 18: Now living in Beili, shaoyaoju, Chaoyang District.

Asymptomatic infected person 19: Now living in Bairong Jiayuan, Dongcheng District.

Asymptomatic infected person 20: now living in Linyuyuan, the ocean side of Chaoyang District.

All of the above are social screening personnel, and were diagnosed as asymptomatic infected persons on November 14th.

Asymptomatic infected persons 21 to 31: currently living in Dongcheng District;

Asymptomatic infected people 32 to 39: currently living in Xicheng District;

40 to 86 asymptomatic infected people: now living in Chaoyang District;

Asymptomatic infected persons 87 to 97: currently living in Haidian District;

98 to 108 asymptomatic infected persons: currently living in Fengtai District;

Asymptomatic infected persons 109 and 110: currently living in Shijingshan District;

Asymptomatic infected person 111: currently living in Mentougou District;

Asymptomatic infected persons 112 to 115: currently living in Fangshan District;

Asymptomatic infected persons 116 to 129: currently living in Tongzhou District;

Asymptomatic infected persons 130 and 131: currently living in Shunyi District;

Asymptomatic infected persons 132 to 148: currently living in Changping District;

Asymptomatic infected persons 149 to 155: currently living in Daxing District;

Asymptomatic infected person 156: now living in Huairou District;

Asymptomatic infected persons 157 and 158: currently living in Pinggu District;

Asymptomatic infected person 159: now living in Yanqing District.

All of the above are isolated observers, who were diagnosed as asymptomatic infections on November 14th. Confirmed cases abroad: Confirmed case 1: China nationality, arrived at Beijing Capital Airport from Hong Kong, China on November 11th, and was sent to a centralized isolation hotel through closed-loop management, and was diagnosed as a confirmed case on November 14th. Confirmed case 2: Taiwan, China, who arrived at Beijing Capital Airport from Taiwan, China on November 11th, was sent to a centralized isolation hotel through closed-loop management, and was diagnosed as a confirmed case on November 14th. All the above cases have been transferred to designated hospitals, epidemiological investigations have been carried out, and control measures have been implemented as required. Remind the general public and friends not to go out unnecessarily, not to risk areas, not to have dinners, not to get together, not to visit relatives and friends, not to attend banquets, and not to go to crowded places unless necessary. During nucleic acid testing, we should obey the on-site arrangement, queue up in an orderly manner, wear masks correctly, keep a safe distance, not to gather, not to get together, not to talk less, and leave immediately after testing, and do good hand hygiene. Medical staff, mobile workers, testers, community workers, police officers, volunteers and other frontline epidemic prevention and control personnel should do personal protection. When they are in close contact with high-risk groups, collect and remove garbage, and disinfect the environment, please be sure to wear protective clothing, gloves, N95 masks, protective screens or goggles, shoe covers and other protective articles, and do a good job in hand hygiene to ensure their own health and safety.

The Ministry of Transport issued the "National Key Operating Vehicles"
Notice of the management measures for the assessment of networked joint control systems

Jiao Yun Fa [2014] No.267　　　

All provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps Transportation Department (bureau, committee):
　　The measures for the assessment and management of the networked joint control system of national key operating vehicles are hereby printed and distributed to you, please follow them.

Ministry of Transport　　　　　　 　
December 31, 2014　　　

　

Measures for the assessment and management of networked joint control system of key operating vehicles in China

Chapter I General Principles

　　the first　In order to strengthen the dynamic supervision of national key operating vehicles, standardize the dynamic supervision and management behavior of road transport vehicles, implement the main responsibility of road transport enterprises, and improve the level of road transport safety management, these measures are formulated in accordance with the Measures for the Dynamic Supervision and Management of Road Transport Vehicles (Order No.5 of the Ministry of Transport, the Ministry of Public Security and the State Administration of Work Safety in 2014) and relevant regulations.
　　the second　The term "key operating vehicles" as mentioned in these Measures refers to tourist buses, chartered buses, three types of buses to work and dangerous goods transport vehicles.
　　The measures referred to in the national key operating vehicle networked joint control system (hereinafter referred to as networked joint control system) refers to the dynamic supervision and monitoring system of operating vehicles based on satellite positioning system technology established by road transport management institutions at all levels and related enterprises. The networked joint control system includes the national public service platform for dynamic information of road transport vehicles (hereinafter referred to as the national platform), the supervision platform of local government management departments (provincial, prefecture-level and county-level), the monitoring platform of road transport enterprises and the socialized monitoring platform.
　　The assessment management of all levels and platforms of networked joint control system shall abide by these measures.

Chapter II Assessment Contents

　　Article　According to the management responsibilities of all parties of the networked joint control system platform and the principle of classified assessment, the assessment indicators of platform operation, the assessment contents of road transport management institutions and the assessment contents of road transport enterprises are formulated.
　　Article 4　Assessment indicators based on the operation of the platform include:
　　(1) Vehicle access rate: the ratio of the number of vehicles that transmit dynamic information to the superior platform at least once as of a certain statistical time point to the total number of vehicles in their respective jurisdictions or key operations of the enterprise.
　　(2) Vehicle on-line rate: refers to the ratio of the number of vehicles that normally upload data to the superior platform during the statistical period to the number of vehicles that enter the network in their respective jurisdictions or key operations of the enterprise.
　　(3) Platform disconnection rate: refers to the ratio of the total interruption time of data transmission between the lower platform and the higher platform to the total duration of the statistical period (in minutes).
　　(4) Data failure rate: refers to the ratio of the number of unqualified data such as license plate number, license plate color, time, longitude, latitude, speed, direction, altitude, etc. in the vehicle data uploaded by the lower platform to the number of reported data during the statistical period.
　　(5) Vehicle online time rate: refers to the ratio of the total online time of vehicles (in minutes) to the total operating time during the statistical period. The total duration of vehicle operation can be obtained from the passenger network ticketing system, the passenger station electronic newspaper class system, the tourist charter management system, the dangerous chemicals electronic waybill system and other information systems. The total on-line time of vehicles can be obtained from the statistics of networked joint control system.
　　(VI) Platform post inspection response rate: refers to the ratio of post inspection response times to post inspection times when the government supervision platform sends post inspection instructions to the enterprise monitoring platform irregularly during the statistical period, and the monitoring personnel respond in time (within 5 minutes) after receiving the post inspection instructions. The number of post inspections shall not be less than once a day.
　　(7) Over-speed vehicle rate: refers to the ratio of the number of vehicles reporting over-speed information in accordance with the vehicle speed limit standard set by the public security traffic management department during the statistical period to the number of key operating vehicles in the statistical period of the unit.
　　(8) Handling rate of speeding vehicles: refers to the ratio of the number of vehicles that reported speeding information and were handled by the enterprise in time during the statistical period to the number of key operating vehicles reported by the unit.
　　(9) Fatigue driving rate: refers to the ratio of the number of vehicles reporting fatigue driving information to the number of key vehicles on the line during the statistical period according to the driver’s continuous driving time limit standard set by the public security traffic management department.
　　(X) Handling rate of fatigue driving vehicles: refers to the ratio of the number of vehicles that reported fatigue driving information and were handled by the enterprise in time during the statistical period to the number of key operating vehicles reported by the unit.
　　(11) Real-time online rate of vehicles: refers to the ratio of the number of vehicles connected in real time and normally uploading dynamic information at a certain statistical time point to the number of vehicles connected to the network in the area under its jurisdiction or the key operation of this enterprise.
　　Article 5　The assessment contents of road transport management institutions at all levels include:
　　(a) the construction of the system, the formulation of the management rules and regulations of the networked joint control system in the jurisdiction, and the operation and maintenance management system of the supervision platform; The formulation of emergency plan for fault handling, management measures for operation and maintenance assessment, step-by-step assessment and notification system;
　　(2) Monitoring the operation of the platform, including: vehicle access rate, vehicle online rate, platform disconnection rate, data unqualified rate, and vehicle real-time online rate (this indicator is used as a reference indicator);
　　(three) the implementation of the supervision platform operation and maintenance budget;
　　(four) other measures to ensure the long-term stable operation of the supervision platform.
　　Article 6　The assessment of road transport enterprises includes:
　　(a) the system construction, including: the construction, use and management of the monitoring platform of this enterprise, and the management and assessment methods for the operation and maintenance of the monitoring platform; Installation, use and maintenance system of satellite positioning device; Job responsibilities and management system of monitoring personnel; Traffic violation dynamic information processing and statistical analysis system; Emergency handling system, etc.;
　　(2) Monitoring the staffing situation, including the staffing quantity, personnel education and training, job responsibilities and the implementation of workflow;
　　(3) Real-time monitoring of vehicles, including vehicle access rate, vehicle online rate, vehicle online time rate, speeding vehicle rate, speeding vehicle handling rate, fatigue driving vehicle handling rate and fatigue driving vehicle handling rate;
　　(4) Monitoring the operation of the platform, including: platform disconnection rate, data failure rate and platform post inspection response rate;
　　(5) The data storage of vehicles and the archiving of illegal driving and handling information (dynamic monitoring data shall be kept for at least 6 months, and illegal driving information and handling information shall be kept for at least 3 years).

Chapter III Division of Responsibilities

　　Article 7　The Ministry of Transport is responsible for the assessment and management of the national platform and provincial supervision platform of networked joint control system.
　　Article 8　China Traffic and Communication Information Center is responsible for the operation and maintenance of the national platform of the networked joint control system and the statistical work of the operation assessment indicators of the provincial supervision platform.
　　Article 9　Road transport management institutions at all levels shall organize the assessment and management of the intranet joint control system within their respective jurisdictions, and be responsible for organizing the implementation of the assessment and management of the lower supervision platforms; City and county road transport management institutions are responsible for the assessment and management of the monitoring platform of road transport enterprises in their respective jurisdictions, and fulfill their safety supervision responsibilities.

Chapter IV Assessment Procedures and Application of Assessment Results

　　Article 10　The assessment cycle is divided into monthly and annual. The monthly assessment is conducted in natural months, and the annual assessment cycle is from January 1st to December 31st each year. The assessment takes the form of system automatic statistical analysis as the main part, supplemented by on-site situation investigation.
　　Article 11　The assessment of various platforms at all levels shall be based on the scoring system. Road transport enterprises in any of the following circumstances, the assessment results recorded as 0 points; The road transport management institution has the second situation, and the assessment result is 0:
　　(1) Destroying the satellite positioning device and maliciously interfering with or shielding the signal of the satellite positioning device;
　　(2) Forging, tampering with or deleting vehicle dynamic monitoring data.
　　Article 12　Establish a regular notification system for assessment results of various platforms at all levels.
　　The Ministry of Transport shall notify the assessment results of the provincial supervision platform and send a copy to the transportation departments (bureaus and commissions) of all provinces, autonomous regions and municipalities directly under the Central Government.
　　The provincial road transport management institution shall notify the assessment results of the prefecture-level supervision platform, and send a copy to the local transportation authorities.
　　The assessment results of transport enterprises shall be announced by the road transport management institution responsible for their assessment management through websites and other forms.
　　If the assessed unit has any objection to the assessment results, it may appeal to the assessment unit for verification. If the assessment results are wrong, it shall be corrected in time.
　　Article 13　The assessment results of road transport management institutions should be used as the basis for departmental evaluation and annual target assessment.
　　Article 14　The assessment results of road transport enterprises are included in the content of enterprise quality credit assessment, which is an important basis for the bidding and annual inspection of transport enterprises.
　　Article 15　Problems found in the assessment of road transport management institutions and road transport enterprises should be rectified in time.

Chapter V Supplementary Provisions

　　Article 16　The transportation departments of all provinces, autonomous regions and municipalities directly under the Central Government may formulate assessment methods for government supervision platforms, transportation enterprise monitoring platforms and socialized monitoring platforms within their respective jurisdictions in light of these measures and actual conditions.
　　Local road transport management agencies can assess the service quality of operators according to local actual conditions.
　　Article 17　Rural passenger vehicles are selected and implemented by the provinces according to the actual situation.
　　Article 18　The Ministry of Transport shall be responsible for the interpretation of these Measures.
　　Article 19　These Measures shall come into force as of the date of promulgation.
　　Attachment: 1. Monthly Assessment Form of National Key Operating Vehicle Networking Joint Control System (road transport management institution)
　　　　　2. Annual Assessment Form of National Key Operating Vehicle Networking Joint Control System (road transport management institution)
　　　　　3. Monthly Assessment Form of National Key Operating Vehicle Networking Joint Control System (road transport enterprises)
　　　　　4. Annual Assessment Form of National Key Operating Vehicle Networking Joint Control System (road transport enterprises)
　　(The above attachments are omitted, please visit the website of the Ministry of Transport for details.)　

　　According to Weibo released by @ Ningbo, zhenhai district, Ningbo reported that 3 cases of COVID-19 were positive for nucleic acid. The contents of the notification are as follows:

　　At about 16:30 on December 5, 2021, I received a routine nucleic acid sampling test report from zhenhai district Longsai Medical Group, and a 1:10 mixed sampling test result was abnormal. After receiving the first inspection report, the municipal and district levels immediately responded and acted quickly. Ten sampling objects were observed in isolation at the first time, and professionals were organized to carry out epidemic verification, epidemiological investigation, and re-examination of single-tube specimens, and various epidemic prevention and control measures were implemented. At 20:30 on the 5th, the district CDC detected that one of them was positive for the initial screening, and the other nine were negative. Immediately, the samples of the infected person with the initial screening were rechecked and the results were positive. At the same time, four family members living with the initial screening positive infected person were urgently investigated and sampled. At 4:00 on the 6th, the nucleic acid test results were positive for two people, namely their mother and wife, and the nucleic acid test results for two children were negative.

　　At present, 3 cases of positive infection have been sent to designated hospitals for isolation treatment. The municipal party committee and the municipal government started the emergency response at the first time, organized the work of tracing the source, isolation and control, nucleic acid detection, etc., and carried out environmental sampling detection and disinfection of their activity sites, and implemented control measures for the corresponding areas. The follow-up situation will be announced to the public in a timely manner.

Summer is full, and the sun is just right.

It’s graduation season.

It is also the harvest season.

UCASer keeps innovating and making progress.

New discovery of two new "four quark states" hadrons

New progress of eggshell of Hami pterosaur

Reveal the carbon cycle mechanism of vitamin community in biological crust

… …

With Guo Xiaowei

Look at the latest issue of scientific research express

01 led the discovery of two new "four quark states" hadrons.

Progress has been made in the study of eggshell composition of Hami pterosaur

Joint research and publication of high quality reference genome of Arabidopsis thaliana

Progress has been made in the study of epigenetic mechanism of perfluorooctanoic acid exposure interfering with reproductive endocrine.

USP7 degradation agent was proposed as a potential therapeutic strategy for p53 mutant cancer.

Revealing the carbon cycle mechanism of microbial community in biological crust

Revealing the evolution mechanism of microstructure of sulfur dioxide aerosol by Dalian light source

08 reveals the ligand recognition and G protein selection regulation mechanism of some serotonin family receptors.

Cloning of important genes regulating soybean grain size and quality

Click on the corresponding title below to read the original report.

Click on the journal name to learn more.

Leading the Discovery of Two New Quaker Hadrons Recently, the LHCb International Cooperation Group of the Large Hadron Collider at CERN announced the discovery of three new exotic particles: a new five quark hadron and two new four quark hadrons which are mutually adjoint states. Among them, two "four quark states" hadrons were discovered by the particle physics team of National Science and Technology University, one with two charges and the other neutral. Their internal structure is very strange: they contain four different types of quark components, and their mass is about 3.1 times that of protons.

This is the first time that a double-charge "four-quark state" hadron has been discovered experimentally, and it is also a hadron partner that has found two completely new quark components at the same time. At the same time, the discovery of these two "four quark states" hadrons provides brand-new experimental evidence for confirming the existence of new material forms beyond the conventional baryons and mesons in nature, which will help deepen human understanding of the most basic structure of matter in the universe. Undergraduate and graduate students of the National Science and Technology University played a key role in it.

Mars, a doctoral supervisor of the National Science and Technology University and a doctoral student of Wang Xiaolin, a researcher at the Institute of vertebrate paleontology and Paleoanthropology of the Chinese Academy of Sciences, cooperated with Luo Wugan, an associate professor at the School of Humanities of the National Science and Technology University, to analyze and study the egg fossils of Hami pterosaur in Tianshan Mountain. The results revealed that the main component of the protein-colored eggshell of the pterosaur was fluorapatite.

This study is of great significance to the research and protection of pterosaurs and pterosaur egg fossils. Related research results were published in Heritage Science. Mars is the first author, and Wang Xiaolin and Luo Wugan are the corresponding authors.

Collaborately researching and publishing high-quality reference genome of Arabidopsis thaliana, Wang Ying, an associate professor at the School of Life Sciences of the National Science and Technology University of China, cooperated with Jiao Yuling, a doctoral supervisor at the National Science and Technology University of China and a researcher at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, and obtained a nearly complete reference genome Col-PEK of Arabidopsis thaliana Col-0 ecotype by combining long-reading ONT, high-fidelity long-reading PacBio HiFi and short-reading Illumina NovaSeq sequencing data. Col-PEK assembly filled most gaps in all regions including five centromeres.

The related research was published online in Molecular Plant with the title of "A Near-Complete Assembly of an Arabic Genome". Hou Xueren, a doctoral student at National Science and Technology University, is the first author, and Wang Ying and Jiao Yuling are co-authors.

Progress has been made in the study on the epigenetic mechanism of perfluorooctanoic acid exposure interfering with reproductive endocrine. Huang Qingyu, a graduate tutor of National Science and Technology University and a researcher at the Institute of Urban Environment of Chinese Academy of Sciences, revealed the mechanism of histone modification in PFOA interfering with male reproductive endocrine by analyzing the effects of low-dose PFOA exposure on the expression of key genes in testosterone synthesis, the level of hormone synthesis and the status of histone modification (methylation/acetylation) in rats.

The research results were published in environmental science & technology with the title of "low levels of perfluoro petrochemical acid exposure activations steroid hormone biosynthesis through reproducing histone methylation in rats". Han Xueying, a master student of National Science and Technology University, and Md Nur Alam, a doctoral student, are co-first authors, and Huang Qingyu is a correspondent author.

USP7 degrading agent was proposed as a potential therapeutic strategy for p53 mutant cancer. Zhou Bing, Li Jia and Zhou Yubo, doctoral supervisors of National Science and Technology University of China and researchers of Shanghai Institute of Pharmacology, Chinese Academy of Sciences, designed and synthesized the first small molecular probe U7D-1 with high efficiency and selective degradation of USP7, and studied its antitumor activity and mechanism in p53 wild-type cells and p53 mutant cells.

The related research work was published online in angew.chem.int.ed. with the title of "discovery of a potential and selective degrader for USP 7". Pei Yuan and Fu Jingfeng, Ph.D. students of National Science and Technology University, and Shi Yunkai, postdoctoral fellow of Hangzhou Institute of Advanced Studies of National Science and Technology University, are co-first authors. Zhou Bing, Li Jia and Zhou Yubo are co-authors.

Ho Xuan Huong, a doctoral supervisor of National Science University of China and a researcher of Institute of Hydrobiology, Chinese Academy of Sciences, conducted five batches of sampling surveys for four consecutive years on biological crusts (algae crusts, cyanobacteria lichen crusts, green algae lichen crusts and moss crusts) in different succession stages of typical field plots. By using various metagenome technologies and big data model analysis methods, combined with the determination of enzyme activities at physiological level and the correlation analysis of environmental factors, the microbial carbon cycle pattern and its interaction and regulation mechanism of biological crusts were revealed.

The related research results were published online in Soil Biology and Biochemistry with the title of "carbon cycle in the microbial ecosystems of biological soil crusts". Wang Qiong, a doctoral student at National Science and Technology University, is the first author, and Ho Xuan Huong is the correspondent author.

Using Dalian light source to reveal the microstructure evolution mechanism of sulfur dioxide aerosol, Jiang Ling, a graduate tutor of National Science and Technology University of China, a researcher of molecular reaction dynamics State Key Laboratory of Dalian Institute of Chemistry, Chinese Academy of Sciences, and Zhang Zhaojun, an associate researcher, discovered the structural evolution mechanism of sulfur dioxide hydrated clusters by using a self-developed infrared spectrum experimental device based on Dalian coherent light source, which provided a new idea for understanding the nucleation mechanism of sulfur dioxide aerosol. This achievement helps to clarify how pollutant molecules grow into clusters step by step, so as to help people better understand the formation mechanism of smog.

The related results were published in the Journal of Physical Chemistry Letters with the title of "Infrred Spectroscopy of Stepwise Hydration Motives of Sulfur Dioxide". Chong Wang and Fu Liangfei, Ph.D. students of National Science and Technology University, are co-first authors.

Revealing the ligand recognition and G protein selection and regulation mechanism of some serotonin family receptors, led by Xu Huaqiang, a doctoral tutor at National Science University and a researcher at Shanghai Institute of Pharmacology, Chinese Academy of Sciences, together with Zhang Yan, a professor at Zhejiang University, and David E. Gloriam, a professor at Copenhagen University, Denmark, etc. The research results "gpcrs steergi and GS selectivity via tm5-tm6 switches as revealed by structures of serotonin receivers" were published online on Molecular Cell. Huang Sijie and Xu Peiyu, Ph.D. students of National Science and Technology University, Shen Dandan, research assistant of School of Basic Medicine of Zhejiang University, and Icaro A. Simon, University of Copenhagen, Denmark are the co-first authors of this paper.

This study has made another progress in the field of structure and function of serotonin receptor, and successfully analyzed the three-dimensional structure of 5- HT, 5-HT, 5-HT receptor and activated G protein (Gs protein) and 5-HT receptor and inhibited G protein (Gi protein). The structural basis of small molecular ligands 5-HT and 5-CT recognizing 5- HT receptor subtypes was revealed, and the molecular mechanism of 5- HT receptor selectively coupling Gs protein and Gi protein was clarified. Huang Sijie and Xu Peiyu, Ph.D. students of National Science and Technology University, Shen Dandan, research assistant of School of Basic Medicine of Zhejiang University, and Icaro A. Simon, University of Copenhagen, Denmark are the co-first authors of this paper.

Tian Zhixi, a doctoral supervisor of National Science and Technology University of China and a researcher of Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, cloned an important gene regulating soybean grain size and quality. Through genome-wide association study analysis of more than 1,800 soybean germplasm resources, a stable signal interval related to grain thickness was identified on chromosome 5, which overlapped with many reported candidate QTL intervals for yield, oil content and protein content. The team further combined with the analysis of multi-omics data to determine a gene GmST05 (Seed Thickness 05) which controls the thickness and size of soybean seeds.

The research results were published online in Plant Biotechnology Journal with the title "Natural Allelic Variation of GMST 05 Controlling Seed Size and Quality in Soybean". Duan Zongbiao, a doctoral student at National Science and Technology University, and Sharla Cheung, an assistant researcher, are co-first authors, and Tian Zhixi is a correspondent.

This issue of scientific research express is here.

Original title: "New progress in scientific research, coming! 》

Read the original text

　　As a special road facility to help visually impaired people walk, an important prerequisite for blind roads is safety and anti-skid. In recent years, with the continuous acceleration of urban renewal in Zhangzhou, the municipal departments of Zhangzhou have upgraded many roads in the old city, and improved the smoothness and comfort of sidewalks, especially the consistency and safety of blind road traffic, by lowering kerb ramps, connecting blind road breakpoints and repairing damaged pavement bricks. However, there are still many citizens who report that there is a "skid" phenomenon in the blind roads passing through some sections. Is the blind road in Zhangzhou safe and anti-skid? The reporter visited and investigated this.

Venue: Shengli West Road (Xiyangping to Zhangzhou No.1 Middle Section)

Blind road: newly paved permeable brick　

Shengli West Road (Xiyangping-Zhangzhou I Middle Section), which just resumed traffic a few days ago, has a large traffic volume, and pedestrians and electric vehicles travel intensively. The red and gray blocks on the newly paved sidewalk clearly distinguish non-motor vehicle lanes from pedestrian walkways. On the gray pedestrian passage, the yellow blind road paved with permeable bricks is particularly eye-catching.

▲ The blind road of Shengli West Road (Xinhuadu section) is clearly distinguished.

The reporter tried to walk blindfolded on the blind road of this section, and there was a clear concave-convex feeling under his feet. The strip-shaped blind road brick indicating the forward direction was basically the same as the permeable concrete pavement on both sides, and there was no discomfort when he accidentally stepped on the brick surface. The blind road paving brick at the end of the road section has been changed into a round stop brick, and a long gentle slope has also been set when getting off the curb. During the hundreds of meters’ journey, except for the tension caused by "invisibility", there is no feeling of slipping under the feet. Subsequently, the reporter poured water on the brick surface to experiment, and the water quickly penetrated into the brick surface, and there was also a clear sense of friction when stepping on it again.

"Laying blind roads with materials with strong water permeability can minimize water accumulation in rainy days and prevent special people from slipping when passing." The person in charge of the Engineering Department of the Municipal Engineering Center told the reporter that in the reconstruction of this section, Zhangzhou chose silica sand permeable blind brick, and the surface of the brick has many small concave and convex points, which is not only good in water permeability, anti-skid and weathering resistance, but also has the characteristics of noise reduction and sound absorption, which can slightly absorb the noise generated by vehicles while preventing the road from slipping.

Blind roads not only pay attention to non-slip in material design, but also pay attention to the location of laying. "In this renovation, we laid the sidewalk close to the inner side of the building along the street, and the blind road was set in the middle of the sidewalk, as far as possible away from the non-motor vehicle lane, to avoid the non-motor vehicle from accidentally pressing the blind road and slipping to the greatest extent." The person in charge of the project of Zhangzhou Chengtou Municipal Investment Group said that although the original intention of setting the blind road was to provide guidance for the blind on the sidewalk, many citizens would "borrow the road" to ride on the sidewalk when the traffic volume was heavy during the rush hour. If you just ride the strip guide bricks on the blind road at this time and the speed is too fast, it is very likely that the tires will slip and yaw. Especially in rainy days, when driving an electric vehicle through the blind road, it is very easy to slip and swing when changing speed, braking suddenly and turning because of the small tires and weak friction.

"Sometimes when I walk, I will meet someone riding a bicycle in the opposite direction on the sidewalk, and the speed is quite fast. In order to avoid them, I often have to dodge in a hurry. As a visually sound person walking on the road, there are still so many hidden dangers. It is hard to imagine what a blind friend should do if he encounters such a situation when walking in a blind road. " In the view of citizen Huang Ruzhen, electric vehicles should try their best to take non-motor vehicle lanes. When it is really necessary to "borrow roads" to walk on sidewalks, cyclists should also slow down and be polite to pedestrians, and avoid riding in blind areas. Pedestrians should also avoid blind roads when walking. "Don’t occupy blind roads just for the sake of convenience. After all, blind roads are designed for blind people to pass, not for cycling. Only when everyone goes his own way and abides by the rules can the possible hidden dangers be fundamentally eliminated, which also reflects the civilized quality of our citizens. " Huang Ruzhen said.

Venue: Bridge deck of Xinpu Road (Danxia Road to Jiulong Avenue)

Blind road: hot melt marking　

Water-permeable brick has become a new darling in road construction in recent years because of its good water-permeable and anti-skid performance and high safety factor, and is used in more and more municipal road projects. However, in the early road construction before the rise of permeable bricks, the blind roads in some sections of the old city were mainly made of colored bricks, marble slabs and thunderbolt bricks, with different water permeability and anti-skid performance, and many cycling skidding incidents that made the citizens complain often occurred in such sections.

On June 10th, a news report that "the blind road became a slipway and the citizens slipped on rainy days" triggered a heated discussion among many citizens. The reporter visited the bridge deck sidewalk of Xinpu Road (Danxia Road to Jiulong Avenue), where the incident occurred, and found that the blind road in this section had been re-bricked, fenced and set up warning signs.

According to the person in charge of the construction unit, the road section was located in the red line of the bridge, and the early construction was limited by the objective conditions such as insufficient height of the original sidewalk. In order to avoid affecting the bridge structure, only a thin color brick material was selected at that time, although it met the national regulations and there were suppressed strip-shaped blind lines, but with the extension of service life, there was a real risk of slippery when riding through the brick surface in rainy days. Because of the particularity of this section, it is impossible to use thick permeable bricks for laying. In this reconstruction, the construction unit used hot melt materials to mark the blind road guide line.

"In fact, we have rectified this section many times. Because of the limitation of bridge deck construction, we have tried different materials to lay it. Although it is not as high as water permeable bricks, the friction under the feet is enough when the blind people pass through the rectification, even if they walk in rainy days, it is safe. " The person in charge of the construction unit has no choice but to say that whether the blind road is selected with permeable bricks or hot-melt materials, the target object is the blind after all. Non-motor vehicles will "borrow roads" to crush the blind road for a long time, which will lead to excessive load bearing of the paving bricks and serious wear of the brick surface, so the blind road bricks often break and need to be replaced frequently.

"If it is damaged, it will have to be renovated and replaced with bricks. If it is renovated, it will have to be blocked for construction. It is inconvenient for everyone to travel and resentment will be even greater. This is a vicious circle." Xiao Junjie, a resident of a nearby community, sighed.

Coincidentally, the blind road on Zhongshan Bridge is paved with stainless steel due to its special location and early design planning. The reporter saw at the scene that the stainless steel blind road next to the pavilion in the bridge has clear bar and dot indication graphics, but there are many non-motor vehicles parked on the blind road, which has caused obstacles in barrier-free facilities, and the occupied blind road has become a "broken road". "Every time we walk through here, we don’t feel the skid under our feet, but the vehicles touched by the blind guide often make us feel that there is no way to go." Chen Tengwen, a visually impaired person, said helplessly.

▲ Blind Road Dot Stop Brick on Zhongshan Bridge

The person in charge of the Engineering Department of Zhangzhou Municipal Engineering Center told the reporter that in view of the unreasonable layout, non-conforming settings and materials of some blind roads in the early construction, Zhangzhou has continuously intensified its rectification efforts in recent years, focusing on the setting and safety of blind roads while upgrading the sidewalk pavement, so that the blind roads can be "excellent" and more convenient for visually impaired people to pass. At present, the blind roads of Yimin Road, Nanchang Road, Narcissus Street, Yuanguang North and South Road, Xinhua South Road, Ruijing Road, Daxi Lane, Qingnian Road, Shiyuan West Road, Beicang Road, Xiabei Road, Zhishan Park Road, Gan Tang Road, Huimin Road, Jinling Road, Shengli Road and Zhangxiang Road in the central city have all been updated with water-permeable bricks and sand-based water-permeable bricks with good anti-skid performance.

Related links: Creating a civilized city needs you and me to "help the blind"　　 　　 　　 　　 　　 　　 　　 　　 　

When the reporter blindfolded and tested whether the blind road was anti-skid from the visual angle of the blind, it was less than 100 meters away and he was frightened.

In the invisible world, I only hear the occasional sound of cars passing by. I was accidentally hit by a passerby who was in a hurry, so I had to stop at once, grope for the concave and convex feeling of the blind road by my feet, find the right direction and take my feet carefully again. A section of the road that can usually be completed in a minute or two, this time it was abruptly "moved" with its feet for more than 20 minutes. Fear is the only thought in my heart; The road under your feet is the only "real thing" that can be touched in the dark world.

The original intention of the experiment is to test whether the blind road is anti-skid, but the process of the experiment can not help but make people think: in a civilized city, can good barrier-free facilities really help the blind to travel? The safety, convenience and comfort of the passage of special people not only test the level of urban builders and managers, but also torture the moral and civilized level of citizens.

Of course, the blind road should be anti-slip, and civilized behavior should be "anti-slip". The blind road is the eyes of the blind. When we park motor vehicles and non-motor vehicles on the blind road, when we put breakfast stalls and newsstands on the blind road, when we ride on the blind road at will, the bricks are damaged, which is like blinding the blind and making them struggle.

A narrow blind road reflects the "people-oriented" concept that runs through the development of modern urban civilization, and also reflects the temperature of the city. Only by paying attention to the details of the construction and caring for the daily trifles can we really weave a "civilized network" to protect and serve special people, so that visually impaired people living in this city can feel more sense of security and happiness in the dark world. The creation of a civilized city needs you and me to "help the blind".

Source: Minnan Daily, Municipal Engineering Center.

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