The 2017 ＂Top Ten Scientific and Technological Progress in Chinese Colleges and Universities＂ project was announced.
A few days ago, the 2017 "Top Ten Scientific and Technological Progress of Chinese Colleges and Universities" organized and selected by the Science and Technology Committee of the Ministry of Education was announced in Beijing after the evaluation process of college declaration and publicity, formal review, preliminary evaluation of the department and final review of the project.
The selection of "Top Ten Scientific and Technological Progress in Chinese Colleges and Universities" has been held for 20 times since it was launched in 1998. This selection activity has played a positive role in improving the overall level of science and technology in colleges and universities and enhancing their scientific and technological innovation ability, and has had a great social impact and won a high reputation.
The list of selected projects in 2017 (attached) is now published. The list of selected projects is sorted according to the phonetic order of the host unit, in no particular order.
List of Selected Projects of "Top Ten Scientific and Technological Progress of Chinese Colleges and Universities" in 2017
Note: Sorted according to the phonetic order of the reporting host, in no particular order.
Introduction of Selected Projects of "Top Ten Scientific and Technological Progress in Chinese Colleges and Universities" in 2017
1. Research on the new principle of light field regulation in asymmetric microcavity.
The conservation of momentum is one of the objective laws of nature, which reflects the nature of time and space. The generalized momentum of a closed system always remains unchanged. As one of the main physical systems to enhance the interaction between light and matter, the direct coupling between optical microcavity and external light field needs to meet the momentum matching condition, but it is often only realized in a narrow spectral range, which makes the broadband optical physics and application of microcavity face challenges.
Academician Gong Qihuang and researcher Xiao Yunfeng of Peking University’s "extreme optics innovation research team" put forward a new principle of chaos-assisted photon momentum conversion in asymmetric optical microcavity, which realized efficient and ultra-wide spectrum optical coupling in optical microcavity. Asymmetric optical microcavity breaks the spatial rotational symmetry and regulates the local light field, thus obtaining a quasi-continuous chaotic mode while supporting the discrete echo wall mode. Photons first refract from the nano-waveguide into the chaotic mode of microcavity; Chaotic motion makes the angular momentum of incident photons increase rapidly in picosecond time scale; Then the dynamic tunneling process realizes its efficient coupling with the echo wall mode. Chaos-assisted coupling no longer needs momentum matching between microcavity and waveguide mode photons, and is expected to play an important role in integrated photonics and information processing. In addition, they also used the nonlinear modulation of optical Kerr effect to observe the spontaneous symmetry breaking of microcavity light field for the first time in experiments, and obtained the chiral light field of microcavity.
The research results were published in Science and Physical Review Express respectively, which attracted wide attention from international academic circles, and were featured by more than ten international scientific and technological media such as Phys.org and ScienceDailey, marking that the research on microcavity optics in China has reached a new height.
Second, 5 nm carbon nanotube CMOS devices
Chip is the foundation and driving force of the information age, and the existing CMOS technology will touch its limit. Carbon nanotube technology is considered as an important option in the post-Moore era. Theoretical research shows that carbon nanotube transistors are expected to provide higher performance and lower power consumption, and it is easier to realize three-dimensional integration, and the comprehensive advantages at the system level will be as high as thousands of times, so chip technology may be promoted to a new height. Professor Peng Lianmao’s team from the Department of Electronics of Peking University made a major breakthrough in the physics, preparation technology and performance limit exploration of carbon nanotube CMOS devices, abandoned the traditional doping process, controlled the polarity of the transistor by controlling the electrode material, and suppressed the short channel effect. For the first time, a high-performance carbon nanotube transistor with a gate length of 5 nm was realized, which surpassed the best silicon-based transistor at present and approached the physical limit determined by the principle of quantum mechanics, and it is expected to push CMOS technology to a technical node below 3 nm. On January 20, 2017, the landmark achievement was published online in Science (2017, 355: 271-276) with the title of Scaling Carbon Nanotube Complete Transistors to 5-nm Gate Lengths. It has been publicly and positively cited by peers including IBM researchers for 24 times in journals such as Science and Natural Nanotechnology, and has been selected as a highly cited paper of ESI.Related work was reported by mainstream academic media at home and abroad such as Nature Index, IEEE Spectrum, Nano Today, Science and Technology Daily and Xinhua News Agency. People’s Daily (Overseas Edition) commented that the working speed of carbon tube transistor is three times that of Intel’s most advanced commercial silicon transistor with 14 nm, and the energy consumption is only one quarter of it, which means that China scientists are expected to catch up with their foreign counterparts in chip technology and it is a new milestone in the development of information technology in China.
Third, early intervention of chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is the third major cause of death in China. The prevalence rate of COPD among people aged 40 and above in China is 8.2%, of which 70.6% are early patients with no obvious symptoms. These patients are easily overlooked and missed diagnosis because of their mild symptoms or even no obvious symptoms. When patients have obvious symptoms such as shortness of breath, most of them are in the middle and late stage of the disease. During this period, the treatment effect of patients with chronic obstructive pulmonary disease is poor, and the mortality rate, readmission rate and disability rate are high, which brings a heavy burden to patients’ families and society.
For the first time, the team of Ran Pixin of Guangzhou Medical University carried out a multi-center clinical trial for patients with early chronic obstructive pulmonary disease, and found that inhalation of anticholinergic drug tiotropium bromide can significantly improve the lung function and quality of life of patients with early chronic obstructive pulmonary disease, slow down the annual decline rate of lung function and reduce acute exacerbation. In view of the low popularity of pulmonary function examination and the high missed diagnosis rate of chronic obstructive pulmonary disease in China, a new screening technology for chronic obstructive pulmonary disease was developed, which provided support for early diagnosis and early intervention. In order to cooperate with drug treatment, a community-based stratified and accurate comprehensive prevention and treatment model was established, and it was found that reducing the exposure of biofuel smoke could reduce the risk of COPD.
This study puts forward the early intervention strategy of COPD for the first time. It is suggested that high-risk groups who smoke for a long time and are exposed to polluted air and biofuel smoke should be screened early. Once diagnosed, even if there are no obvious respiratory symptoms, comprehensive intervention measures such as quitting smoking, reducing biofuel smoke exposure and drug treatment should be started in time to prevent further decline of lung function and disease development, and improve the comprehensive prevention and treatment level of COPD.
Four, the key technology and industrialization of high performance CNC system
High-performance CNC system is the foundation of developing high-end manufacturing equipment and represents the core competitiveness of national manufacturing industry. High-performance CNC systems and machine tools, such as high speed and high precision, five-axis linkage, multi-axis and multi-channel, are the bottleneck problems, which seriously affect the social and economic development of our country.
With the support of major national science and technology projects and enterprises, the team of Professor Chen Jihong from Huazhong University of Science and Technology "Industry-University-Research" jointly tackled key problems and developed a series of high-performance CNC system complete products. Build an all-digital and open CNC system software and hardware platform; The control functions such as multi-axis linkage and multi-channel are developed, and the motion control of complex trajectory is realized. A high-speed nano-interpolation method based on flexible acceleration and deceleration is proposed to develop high-speed, high-precision and high-stiffness drive control technology. Invented an analysis method based on big data in command domain, and realized intelligent applications such as health assessment, tool breakage monitoring and process parameter optimization of CNC machine tools. It won 1 second prize of national scientific and technological progress and 5 first prizes at provincial and ministerial levels, forming 13 national and industry standards.
The achievements have been applied to more than 2,000 enterprises such as Shen Fei, Chengfei, No.8 Aerospace Institute, No.9 Nuclear Institute, Pushing Ningjiang, etc., realizing the batch application of high-end CNC equipment and weapons and equipment in aerospace, energy and power, automobiles and their parts, 3C manufacturing, machine tools and other fields, and providing important technical support for the independent control of high-end CNC equipment in China. Appraised by China Machinery Industry Federation, its function, performance and reliability have reached the advanced level abroad, and it can replace imports. In the field of aerospace processing and manufacturing, domestic high-grade CNC has achieved a "zero breakthrough".
Five, deep-sea high-precision underwater acoustic integrated positioning technology
Guided by the deep-sea high-precision underwater acoustic integrated positioning system developed by Harbin Engineering University, China’s "Deep-sea Warrior" manned submersible quickly found the predetermined underwater target in the depth of 3500m in the South China Sea on September 29th this year, and achieved "finding a needle in a haystack", which indicates that China’s deep-sea high-precision underwater acoustic positioning equipment and technology have reached the international leading level.
Acoustic wave is the only effective information carrier underwater so far, and high-precision underwater acoustic positioning is the key for human beings to rely on many underwater submersibles to enter, explore and develop the deep sea. However, in order to achieve the same positioning performance as satellites underwater, we must overcome the challenges such as complex underwater acoustic channel environment, serious interference from underwater acoustic platform and difficulties in realizing independent intellectual property system.
After eight years of hard work, Professor Sun Dajun’s team has successively overcome key technologies such as deep-sea high-precision ultra-short baseline positioning (won the second prize of national technological invention in 2016), integrated positioning with ultra-short baseline array on water surface and long baseline array distributed on seabed, and solved the problem of asynchronous high-precision positioning with large time delay caused by slow ocean sound speed and platform movement. The underwater acoustic integrated positioning system with independent intellectual property rights (6 invention patents granted in 2017) has been developed, with deep-sea positioning accuracy of 0.3m and positioning efficiency exceeding. Successfully supported the just-concluded maiden voyage test of China’s "Deep Sea Warrior" and the comprehensive investigation and scientific investigation of China’s most advanced scientific research ship "Science" in the South China Sea, laying a solid technical and equipment foundation for China’s deep-sea practice such as scientific exploration of the 10,000-meter abyss "Mariana Trench".
Six, high orbit satellite-ground two-way high-speed laser communication system technology
The technology of high-orbit satellite-ground bidirectional high-speed laser communication system is one of the frontier scientific fields related to the overall situation and long-term development strategy of the country. The successful completion of the project marks that China has reached the international forefront in the field of space laser communication and is another new milestone in the field of satellite communication.
Satellite laser communication has the advantages of large communication capacity, long transmission distance and good confidentiality. It is an irreplaceable means to build a space information superhighway, and it is also the frontier science and technology in the current international information field. Satellite-to-ground laser communication in high orbit needs to achieve high-precision capture between the satellite and the ground station, effectively overcome the influence of satellite motion, platform jitter, complex space environment and other factors, and maintain the continuous high-precision and stable alignment of the laser beam, which is extremely difficult in technology and is a hot spot that countries are competing to develop at present.
On April 12, 2017, the laser communication terminal developed by Tan Liying of Harbin Institute of Technology was launched into orbit with the satellite. From May to August, 2017, the high-orbit satellite-ground bidirectional high-speed laser communication system realized "precise alignment, stable maintenance and high-speed communication" between the satellite and the ground station with a distance of nearly 40,000 kilometers. The two-way high-speed information transmission channel between satellite and ground established by laser beam has successfully carried out communication data transmission, real-time forwarding and storage forwarding with the highest transmission data rate of 5 Gbps per second, which is the highest transmission data rate of high-orbit satellite laser communication in the world so far, and its performance and technical indicators have reached the international leading level.
The two-way high-speed laser communication system between high orbit satellite and earth has established a high-speed backbone channel in the information network between heaven and earth, which has laid an important foundation for the establishment of an integrated information network between heaven and earth in China in the future.
Seven, "bait mode"-a new mechanism of pathogenic bacteria
Crop diseases caused by Phytophthora were once called "plant plagues", which seriously threatened global food and ecological security. In the mid-19th century, the European potato late blight epidemic caused millions of people to starve to death or flee, and this "Irish famine" was called a turning point in human history. At present, the annual losses caused by epidemic diseases in the world are still as high as more than 20 billion dollars. Crop diseases break out and spread quickly in the field, causing serious harm. Because of the complex genome of Phytophthora and the lack of understanding of pathogenic mechanism, the research and development of prevention and control technology is seriously restricted.
Team Wang Yuanchao of Nanjing Agricultural University systematically studied the action mechanism of Phytophthora effector around the main weapon "effector" that Phytophthora attacks plants. It was found that Phytophthora can secrete glycosyl hydrolase XEG1 to degrade plant cell walls, while plants secrete protease inhibitor GIP1 to inhibit the activity of XEG1. The inactivated mutant XLP1, which can secrete hydrolase, acts as a "bait" to interfere with the defense response, and cooperates with XEG1 to attack plant disease resistance. In addition, it was also found that Phytophthora secreted effector into host cells to destroy plant disease resistance by interfering with histone acetylation.
This achievement was published in Science, Current Biology and New Phytologist in 2017, and was reviewed by many magazines such as Nature chemical biology. The "bait model" found in this study is a brand-new pathogenic mechanism and a major theoretical breakthrough in the field of biological interaction in recent years. Because this mechanism is universal in pathogenic bacteria, it not only has guiding significance for improving the persistent disease resistance of crops, but also provides new clues for developing new biological pesticides, which has potential application prospects in the field of green production of crops.
Eight, eukaryotic yeast long chromosome chemical reconstruction
Genome design and synthesis is a brand-new design and construction of genome from scratch, which can shape life as needed, open the door of transforming from inanimate matter to living matter, and promote life science research from understanding life to creating life. Genome design and synthesis provides a new way to deepen understanding of basic scientific issues such as life evolution, the relationship between genome and function. However, genome synthesis faces some problems, such as the difficulty of precise synthesis of long chromosomes and cell inactivation caused by synthetic chromosomes.
After more than five years’ exploration, the teams of Yuan Yingjin of Tianjin University, Yang Huanming of shenzhen huada gene research institute and Junbiao Dai of Tsinghua University completed the chemical total synthesis of four long chromosomes of Saccharomyces cerevisiae, and created the rapid localization method of genome defect targets and the precise repair technology of multi-target fragment co-transformation, which solved the problem of cell inactivation caused by chemical synthesis of long chromosomes and realized the complete matching between the synthetic sequence of long chromosomes and the designed sequence. A multi-level modular and parallel chromosome synthesis strategy was created, and the rapid customized synthesis from small molecular nucleotides to eukaryotic long chromosomes was realized. The artificial ring chromosome was constructed, which established a research model for the mechanism and potential treatment of the currently incurable chromosome ring disease.
On March 10th, 2017, this research published four Science papers in the form of long articles, which attracted great attention from experts and media at home and abroad, and was highly praised by articles published in journals such as Science, Nature, Nature Biotechnology, NatureReviews Genetics and Molecular Cell.
Nine, coal supercritical water gasification hydrogen generation and power generation technology
On December 25th, 2016, Xi ‘an Jiaotong University transferred the "Polygeneration Technology for Hydrogen Production and Power Generation from Coal Supercritical Water Gasification" proposed by Professor Guo Liejin and successfully developed by the team for 20 years to Shaanxi CNNC Jiaotong University, an industrialized investment group, at a price of 150 million yuan, which officially started the industrialization of this technology. Over the past year, the team has continued to tackle key problems, developed a system integration and matching method for large-scale engineering cogeneration of this technology, solved the key technologies and auxiliary engineering technologies existing in industrialization, completed the technical design of two large-scale engineering demonstration devices such as cogeneration and hydrogen-heat cogeneration, and promoted the industrial investment group Shaanxi CNNC Jiaotong University to jointly invest 420 million yuan and 500 million yuan in Xi ‘an Chengtou Group and Yulin Environmental Protection Group respectively to carry out the construction of the first demonstration projects of cogeneration systems such as heat, electricity and hydrogen.
This technology can solve the smog-causing coal-fired gas pollutants such as SOx and NOx and dust emission from the source. The mixed product gas composed of supercritical water, H2 and CO2 can be used for hydrogen production, power generation, heat supply and steam supply. CO2 enrichment and resource utilization can be naturally realized in the process, which can improve the coal-electricity conversion efficiency of generator sets by at least 5 percentage points, reduce the one-time investment by 30%, save water and lower the operating cost. The third-party demonstration expert group believes that "the technology has completely independent intellectual property rights, the technology is feasible and the economy is reasonable". Investors believe that this technology "realizes the efficient, clean and pollution-free utilization of coal energy, which will surely bring about profound changes in energy technology and make great contributions to global energy conservation and emission reduction".
Ten, high-speed railway train dynamic effect test system (iHSRT)
The running speed of high-speed railway trains is high, which is close to or exceeds the wave propagation speed of subgrade soil. The vibration generated by train operation can not spread out in time, causing shock wave phenomenon and Mach effect, resulting in excessive vibration and cyclic cumulative settlement of subgrade, which affects train safety and ride comfort. It is of great scientific significance and engineering value to study the dynamic effect of railway subgrade caused by high-speed train operation under controllable conditions in the laboratory.
Academician Chen Yunmin, led by Professor Bian Xuecheng of Zhejiang University, invented the world’s first test device for dynamic effects of high-speed railway trains. The device converts the running load of the train into vertical dynamic load acting on a series of sleepers, and realizes the loading of the subgrade by the high-speed movement of the train axle by accurately controlling the loading phase difference of adjacent vibration exciter. The whole test system consists of train loading exciter array, loading control system, full-scale line model and test system, and the maximum speed is 360 km/h. The core technology won 2 invention patents in the United States and 8 invention patents in China.
Using this system, the Mach effect of saturated subgrade and dynamic soil arching effect of pile-supported subgrade accompanied by the sharp increase of dynamic pore pressure are found, and the dynamic stress amplification effect, attenuation law along depth, cyclic cumulative settlement law and mechanism of excessive settlement in high-speed railway subgrade are revealed. Based on this, the evaluation, control and repair methods of subgrade cyclic cumulative settlement are put forward, which have been successfully applied to more than 10 high-speed rail and subway projects on soft soil foundation, and achieved remarkable social and economic benefits. Ten papers were published in international authoritative journals, among which the papers published in Soil Dynamics and Earthquake Engineering were rated as "Most Cited Articles".